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Posts: 264
Reply with quote  #1 
My doctor had put me on amatriptiline 10mg one each night, as i am not in bad pain in my bladder the discomfort and burning is all utherial and anus especially after a wee, also much frequency after a cystoscopy.I really can't see the point of taking this drug if it is not going to calm my bladder down i thought this drug was just for pain.i think it is giving me water retention i am finding it difficult to pass my water today, anyone else had this trouble with this drug.

H.M Whitworth

Posts: 1,762
Reply with quote  #2 
Hi heathwit

I saw this searching earlier.

Amitriptyline works  because it also blocks receptors called cholinergic or muscarinic receptors that are found on the surface of muscle cells in the bladder wall. This action helps the muscle in the bladder wall to relax, which reduces unstable, involuntary contractions of the bladder. This increases the capacity of the bladder to hold urine and reduces the need to pass urine. When used for this purpose, amitriptyline should generally only be used for a maximum of three months.

Forgot where I read so apologies for not giving copyright.

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