We can only say that it's a question of managing expectations. Lots of people jump into treatment and expect that after a week or so things will suddenly get better and then struggle to understand why the pain is sometimes worse or no different. It's often down to several things:
1. Your bugs and symptoms - whilst the bugs may be susceptible to the ab prescribed and be knocked back often another bug occupies the space vacated and you may need another ab or add in naturals such as Oil of Oregano, Grapefruit Seed Extract, D Mannose (if E. coli present or suspected). Symptoms can change depending on the bacteria.
2. How long you have had symptoms. An embedded infection is just that, embedded into the bladder wall so will take time for the cells to shed or release and come to the surface of the bladder wall and become active in the bladder where the antibiotics can target them.
3. Other contributing factors such as hormones, thyroid, Lyme disease, gut health or other illnesses which will weaken your immune system. Some of these you will have to explore and treat to add a piece to your jigsaw.
4. Pelvic floor issues causing additional regional pain
5. Any ab resistances you may have. Bugs are unbelievably adaptive at resisting and mutating.
6 The inflammatory effects of infection in the bladder and body can often take a lot longer to resolve than the infection and these symptoms will take time to resolve.
Dogged persistence is the name of the game here and for some it can take weeks, for others months and for some years. Remember even if you are only seeing 5% improvement each day it's still improvement and whatever you do, don't compare yourself to others on here. That way leads to a downward spiral of negativity. Your bugs, your body, your rules. Focus on your healing and yours alone.
You must give this a good shot and take the good days and bad. If things haven't improved after 6 months or so then decide what you want to do but please try to be patient at first. This is not a quick one week fix. Always keep your specialist informed about your progress. If things worsen significantly or you get a reaction to medication etc. E mail them immediately. Medications can be changed.
If you suffer breathing issues or a tight chest, become dizzy or faint, develop a rash or heart palpitations, stop your medication and get to A&E or the Emergency room. Take all medications and your most recent treatment letter from your specialist with you.
The recovery pathway (a progression of the disease) is classically through a series of horrible flares which come and go. We all go through this. When you are in treatment, each successive flare is progressively milder and you may notice over months you will drop a symptom each time you flare (maybe there will be less pain and the flow will be better but the urgency and frequency will stay and then they will slowly go and the last symptom may be, say, burning, or itching inside the urethra). If you weren't being treated the same ups and downs would be experienced, but maybe each time you flare it will feel worse and worse as it progresses rather than slowly better. It is thought that the reason it comes and goes with "break through flares" is because the bacteria get released when the bladder changes its lining and "spits them out" from inside the bladder wall cells. This can be a natural shedding which the bladder wall does as well as provoking the bladder lining though sex, exercise or eating inflammatory foods. The bacteria are released into the bladder becoming planktonic (active) and the immune system goes on alert and causes all the symptoms. Also, the bacteria release toxins as they die causing more inflammation. More pain = bacteria crying.