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Nia

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Posts: 189
Reply with quote  #1 
I have IC and also get a lot of infections. Is there any devolopments on the vacine for utis. If so did anybody try it? Where is it available? Any side effects?
Moderatorsusan

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Reply with quote  #2 
There are two vaccines available - urovaxxon and uromune. Urovaxxon has been around for several years and has a success rate of around 30%. Uromune is newer developed in Spain and targets the immune system. The COB office has plenty of info they can send you so call them in the morning. It's currently only available via one private urologist in the UK but again the COB office can send you details. He is looking for patients with proven infections on standard and that's the critical word testing. So if you get regular proven infections via NHS you may be eligible. However if you get regular inconclusive insignificant no growth results then he will probably tell you to save your money.
Nia

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Reply with quote  #3 
Thanks Susan. Do you know what the success rate for uromune is?
Moderatorsusan

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Reply with quote  #4 
It's still being tested here in the UK under trial through a urologist so no UK success rates I'm afraid. However trials in Spain have been very positive and they are looking to run a bigger trial this year. Google it and you will find more details.
Czib

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Reply with quote  #5 
I have just started a three month course of Uromune along with a one months course of Trimethoprin which I am nervous about taking as antibiotics haven't worked for me in the past and give me horrible side effects. I really hope the Uromune improves my quality of life as right now I would give anything for a healthy bladder. Will update on my progress
Hannah123

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Reply with quote  #6 
Hi Czib,
How are you getting on with Uromune?
Czib

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Reply with quote  #7 
Well I haven't had a UTI since taking it but hasn't stopped my bladder pain. However, turns out I may have been misdiagnosed could be endemetriosis on the bladder causing me pain rather than my original diagnosis of chronic cystitis
Firefly

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Posts: 34
Reply with quote  #8 
I have been taking Uromune since October and am very pleased with it. No side effects and it has kept me clear of infection. My urologist was happy to prescribe it despite the fact that the majority of my infections were picked by via private broth culture.
Nia

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Posts: 189
Reply with quote  #9 
Anyone find uromune successful ? Does it target all bugs or just specific ones?
Moderatorsusan

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Reply with quote  #10 
Its targeted against 4 bacteria - E coli, Enterococcus Klebsiella and Proteus. All gram negative bacterium.  Have a read of this study which will provide more information.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536982/

Its available here in the UK with certain urologists - you would need to research these and see if it available via NHS prescription or only privately.  
Nia

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Posts: 189
Reply with quote  #11 
Just wondering how people who have taken uromune got on? Is it worth it? Also do you take abs with it? When you come off it, are you still as likely to develop utis again or have you built up some resistance? Do you just take it for 3 months at a time? Sorry for all the questions
Moderatorsusan

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Reply with quote  #12 
Probably best to have a read of these research and trial studies to answer your questions. The second one was written by the manufacturers who are based in Spain. There is more research to be carried out by the developers particularly with regard to randomised control testing but initial results look positive.

Uromune is composed of heat killed inactive strains of Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris and Enterococcus Faecalis in equal amounts so in theory if these bacteria cause UTI like symptoms the body should be able to use the immune system to kill off the infection. Obviously if the infection is caused by other bacteria then the vaccine may not work.

One thing to be aware of. All trials conducted have been on those with PROVEN UTIs on testing before starting treatment and the first UK study detailed below would only accept patients with these proven test results.

http://www.eusupplements.europeanurology.com/article/S1569-9056(17)30206-3/pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536982/

Nia

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Posts: 189
Reply with quote  #13 
Thanks Susan. Is there just one vaccine uromune or is there an older one as well?
Moderatorsusan

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Reply with quote  #14 
Four that have been developed are Urovaxom, Uromune, Urvakol and Urostim. Urovaxom, developed and manufactured in Switzerland, contains 18 heat killed inactive strains of e coli and can be taken to treat infections specifically due to e-coli. Like Uromune it is taken under the tongue (sublingual).

Urovakol, developed and manufactured in the Czech Republic and Urostim, developed and manufactured in Bulgaria are the third and fourth standardised vaccines. These are administered as daily oral tablets containing mixtures of inactivated bacteria. Both formulations contain strains of E. coli, P. mirabilis and E. faecalis, although Urvakol also includes a strain of Pseudomonas aeruginosa, whereas Urostim contains K. pneumoniae. Initial clinical data from animal and patient studies have shown that Urvakol and Urostim have immunostimulating properties. However, clinical trials have yet to be completed showing the efficacy of both of these vaccines.

Vaccines must be taken 2 hours before of after any food, liquid or the brushing of teeth (if using a sublingual version). Vaccines are available on a named patient basis via urologists both privately and via the NHS. More trials are due to take place.

Finally it is important to remember that there is no one antibiotic/antimicrobial rememdy that treats all and often it can take time to find the right combination of treatment to successfully reduce symptoms and the infection. Additionally, other health issues have to be taken into account that affect a person systemically. The length of treatment will vary between person to person. However, always remember as with any type of infection, further UTIs may occur.
Nia

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Posts: 189
Reply with quote  #15 
Thanks Susan Have they all the same success rate? Also do you still continue to take abs with them?
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