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sarah80

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Posts: 14
Reply with quote  #1 
Hi all.

So I’ve had UTI symptoms for 3 months now. This is my fourth attack in 12 months, but the other three all went away with a standard course of antibiotics.

Over the last 3 months I’ve had Trimethoprim, Nitrofurantonin, Cephalexin & Amoxicillin which had no effect. Finally, Ciprofloxacin DID reduce the symptoms, but I believe the bacteria has now developed resistance to it as my symptoms have returned 😔

Does anyone know why this one will have worked when the others didn’t? I’m aware it’s a broad spectrum antibiotic with some nasty side effects.

I believe I may have a biofilm / embedded UTI, but with “clear” urine samples my GP will not prescribe any more antibiotics (& if it is embedded I don’t think a 7 day course will have much effect anyway...)
Clairejane

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Posts: 4
Reply with quote  #2 
Hi Sarah I was the same as you lots of courses of antibiotics- relieved symptoms a bit but they always returned! After about 2 years of trying other options like naturals etc I’ve ended up seeing professor ML who deals with embedded UTIS. His way of treating you is long term antibiotics to eventually clear the infection. I’m 7 months in and am doing well. Not cured yet though!
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Claire Haslam
Moderatorsusan

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Reply with quote  #3 
Dear Clare

It's often about understanding the infection that you have.  It is usually thought that an infection is caused by one bacteria (usually ecoli) but in fact infections can be comprised of more than one bacteria.  It could be that the antibiotics prescribed have simply not picked up the additional bacteria during the urine test and the cipro, because it targets more than bacteria has helped resolve symptoms but not for long enough in terms of length of prescription.

Doctors try to avoid creating antibiotic resistance by using the lowest effective dose for the shortest possible time when treating bacterial infections. Thus not all antibiotics or antimicrobial agents prescribed at insufficient dosage have adequate urine penetration to treat infections especially if offered for an insufficient period of time or dosage.  

Some clinicians are finding that a better tactic is to consider a high dose persistence of the same antibiotic or antimicrobial. Even if the bacteria utilise resources to evade the initial antimicrobial treatment, critically, the length and high dose means that the bacteria will eventually run out of adaptation resources and die.

I would contact the BHUK office tomorrow and get details of specialists who are treating these types of recurrent infections.  They are based in the north and London so it may involve travel but if you are struggling with symptoms again and again and the GP won't prescribe because hey ho dipstick says no then this needs sorting before things worsen.

You may also want to get hold of the book written by Angela Kilmartin - lots of really good info about how to manage attacks, addressing your lifestyle and simple changes you can make to avoid infections in the future.

Don't worry, you have options and BHUK advice line will give you lots of info.
sarah80

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Posts: 14
Reply with quote  #4 
Thanks Clarejane & ModeratorSusan, I have received my info pack from Bladder Health UK & intend to make an appointment with the Professor :-) I'm glad your treatment with him is going well Clairejane!

I've also got Andrea Kilmartin's book, but haven't read it the whole way through yet. 

I'm concerned that I only responded to a broad spectrum, and that I may have burned my bridges with it (ie built resistance) as my symptoms returned *during* the most recent course. I was given four 7 day courses of Cipro, with gaps in between where the symptoms returned. Moderatorsusan, are you saying that is it possible that Cipro may work for me again in the future if it were a long course?
Clairejane

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Posts: 4
Reply with quote  #5 
Sarah Jane don’t worry too much about which antibiotics etc the Professor will start you on one and then if that’s not working he’ll switch you to another one. I’ve been on 3 different ones so far plus Hiprex. He’s so knowledgeable and you can trust he knows what he’s doing😊 good luck!
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Claire Haslam
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